Bernard Payrastre Selected Research

myotubularin

1/2021	Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy.
1/2016	Expression of myotubularins in blood platelets: Characterization and potential diagnostic of X-linked myotubular myopathy.
4/2013	Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo.
1/2012	Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.
5/2011	The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
1/2011	Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.
1/2009	Detection of myotubularin phosphatases activity on phosphoinositides in vitro and ex vivo.
11/2006	A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
7/2006	The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans.
2/2004	Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells.

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Bernard Payrastre Research Topics

Disease

25	Thrombosis (Thrombus) 04/2022 - 04/2007
19	Neoplasms (Cancer) 12/2020 - 07/2003
13	Congenital Structural Myopathies (Centronuclear Myopathy) 01/2022 - 02/2002
9	Hemorrhage 10/2020 - 08/2009
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2012 - 07/2003
6	Thrombocytopenia (Thrombopenia) 01/2022 - 02/2003
6	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 09/2011 - 02/2004
5	Lymphoma (Lymphomas) 06/2014 - 11/2003
5	Infections 12/2013 - 10/2002
4	Muscular Diseases (Myopathy) 10/2017 - 12/2003
4	Inborn Genetic Diseases (Disease, Hereditary) 01/2016 - 07/2003
3	Thromboembolism 06/2019 - 08/2012
3	Osteoporosis 06/2019 - 10/2012
3	Insulin Resistance 01/2019 - 12/2015
3	Venous Thrombosis (Deep-Vein Thrombosis) 12/2018 - 08/2012
3	Sepsis (Septicemia) 10/2018 - 01/2017
3	Inflammation (Inflammations) 01/2018 - 12/2013
3	Oculocerebrorenal Syndrome (Lowe Syndrome) 01/2017 - 07/2003
2	COVID-19 12/2022 - 01/2020
2	Stroke (Strokes) 04/2022 - 01/2019
2	Ischemic Stroke 10/2021 - 01/2019
2	Breast Neoplasms (Breast Cancer) 06/2019 - 10/2012
2	Aortic Valve Stenosis (Aortic Stenosis) 04/2019 - 01/2015
2	Thrombasthenia (Glanzmann Thrombasthenia) 01/2019 - 02/2013
2	Neuromuscular Diseases (Neuromuscular Disease) 10/2017 - 07/2006
2	Obesity 01/2017 - 03/2016
2	Bacillary Dysentery (Shigellosis) 02/2016 - 09/2009
2	Hematologic Neoplasms (Hematological Malignancy) 01/2016 - 05/2009
2	Immune System Diseases (Immune Disorders) 01/2016 - 01/2014
2	Type 2 Diabetes Mellitus (MODY) 07/2015 - 10/2012
2	Bacterial Infections (Bacterial Infection) 06/2014 - 10/2007
2	Atherosclerotic Plaque (Atheroma) 10/2012 - 08/2012
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 08/2009 - 08/2002
1	Thromboinflammation 01/2022
1	Type 4B1 Charcot-Marie-Tooth disease 01/2021
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 11/2019

Drug/Important Bio-Agent (IBA)

19	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2020 - 10/2002
13	LipidsIBA 12/2022 - 11/2003
13	myotubularinIBA 01/2021 - 02/2002
13	Phosphotransferases (Kinase)IBA 12/2020 - 10/2006
9	Proteins (Proteins, Gene)FDA Link 12/2022 - 05/2004
9	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2017 - 08/2002
8	CollagenIBA 12/2019 - 12/2014
7	Estrogens (Estrogen)FDA Link 06/2019 - 08/2012
7	Protein Isoforms (Isoforms)IBA 01/2019 - 03/2010
7	Anaplastic Lymphoma KinaseIBA 06/2014 - 02/2004
6	Pharmaceutical PreparationsIBA 01/2020 - 01/2014
6	phosphatidylinositol 5-phosphateIBA 06/2014 - 03/2006
5	phosphatidylinositol 3-phosphateIBA 01/2021 - 11/2006
4	EnzymesIBA 05/2020 - 11/2015
4	Phosphoinositide PhosphatasesIBA 04/2013 - 10/2007
3	phosphatidylinositol 3,5-diphosphateIBA 01/2021 - 02/2004
3	Agammaglobulinaemia Tyrosine KinaseIBA 12/2020 - 12/2014
3	Tyrosine (L-Tyrosine)FDA Link 12/2020 - 02/2008
3	ibrutinibIBA 11/2019 - 12/2014
3	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 12/2015
3	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 11/2017 - 03/2006
3	Heparin (Liquaemin)FDA LinkGeneric 08/2012 - 02/2003
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 01/2018
2	Hemostatics (Antihemorrhagics)IBA 01/2020 - 02/2013
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 04/2019
2	Epinephrine (Adrenaline)FDA LinkGeneric 06/2019 - 11/2015
2	Progestins (Progestagens)IBA 06/2019 - 01/2017
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/2019 - 01/2017
2	IntegrinsIBA 01/2019 - 03/2010
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2018 - 08/2009
2	phosphatidylinositol 3,4,5-triphosphateIBA 01/2018 - 11/2003
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2018 - 11/2005
2	Inositol Polyphosphate 5-PhosphatasesIBA 01/2017 - 04/2007
2	Estradiol (Delestrogen)FDA LinkGeneric 01/2017 - 08/2012
2	AntibodiesIBA 12/2016 - 08/2012
2	Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)IBA 01/2016 - 02/2013
2	Immunoglobulin G (IgG)IBA 01/2016 - 08/2012
2	Dasatinib (BMS 354825)FDA Link 01/2016 - 08/2009
2	Estrogen ReceptorsIBA 11/2015 - 08/2012
2	Adenosine Triphosphate (ATP)IBA 12/2013 - 08/2009
2	Focal Adhesion Protein-Tyrosine KinasesIBA 08/2012 - 05/2004
2	Pyridinolcarbamate (P23)IBA 09/2011 - 02/2004
2	NucleophosminIBA 09/2011 - 05/2006
2	Fc gamma receptor IIAIBA 08/2009 - 02/2003
2	Inositol (Myoinositol)IBA 04/2007 - 10/2002
2	P-2 (P 2)IBA 04/2007 - 10/2002
2	Messenger RNA (mRNA)IBA 10/2006 - 05/2004
2	Sirolimus (Rapamycin)FDA Link 11/2005 - 03/2005
1	CytokinesIBA 12/2022
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2022
1	VaccinesIBA 01/2022
1	Hematoxylin (Haematoxylon)IBA 10/2021
1	Eosine Yellowish-(YS) (Eosin)IBA 10/2021
1	ActomyosinIBA 01/2021
1	Syk KinaseIBA 12/2020
1	Sertraline (Zoloft)FDA LinkGeneric 10/2020
1	AnticoagulantsIBA 01/2020
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 11/2019
1	acalabrutinibIBA 11/2019
1	bazedoxifeneIBA 06/2019
1	Conjugated (USP) Estrogens (Premarin)FDA Link 06/2019

Therapy/Procedure

8	Therapeutics 01/2022 - 01/2012
3	Thrombectomy 04/2022 - 01/2019
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 06/2019